Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.322


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX2chr3_+_182912769-0.391.4e-01Click!
POU5F1chr6_-_312425930.391.4e-01Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_27508139 3.497 LOC643401
hypothetical protein LOC643401
chr6_-_138862273 2.651


chr10_+_7785235 2.437 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr17_+_24394281 2.424 PIPOX
pipecolic acid oxidase
chr8_-_17797127 2.401 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr4_+_100714995 2.400 MTTP
microsomal triglyceride transfer protein
chr10_+_7785360 2.370 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785290 2.327 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785331 2.315 ITIH2
inter-alpha (globulin) inhibitor H2
chr17_+_24394043 2.232 NM_016518
PIPOX
pipecolic acid oxidase
chr2_+_128644510 2.210 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr4_+_74493918 2.205 ALB
albumin
chr21_+_41663853 1.933 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr4_+_74493174 1.852 ALB
albumin
chr3_+_186529376 1.824 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr17_+_3324096 1.762 NM_001128085
ASPA
aspartoacylase
chr6_+_24465109 1.669 NM_181337
KAAG1
kidney associated antigen 1
chr16_+_70646008 1.583 NM_001126102
NM_005143
HP

haptoglobin

chr4_+_74493331 1.542 ALB
albumin
chr12_-_14887648 1.529 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr11_-_16380967 1.498 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr2_+_113601616 1.427 IL1RN
interleukin 1 receptor antagonist
chr1_+_57093030 1.419 NM_000562
C8A
complement component 8, alpha polypeptide
chr2_+_233443237 1.399 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr4_+_74493266 1.365 ALB
albumin
chr13_-_47885018 1.355 LPAR6
lysophosphatidic acid receptor 6
chr19_-_5789740 1.334 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr2_+_113601608 1.322 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr3_-_150422474 1.309 NM_000096
CP
ceruloplasmin (ferroxidase)
chr6_+_132000134 1.305 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr1_+_165565006 1.275 POU2F1
POU class 2 homeobox 1
chr4_+_74493218 1.262 ALB
albumin
chr15_+_63124760 1.259 NM_178859
OSTBETA
organic solute transporter beta
chr2_+_138438277 1.231 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr10_-_52315436 1.146 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr1_+_165564904 1.139 NM_001198783
POU2F1
POU class 2 homeobox 1
chr19_-_53081326 1.122 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr16_-_54424517 1.109 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr4_+_74493301 1.103 ALB
albumin
chr1_+_144149794 1.071 NM_006472
TXNIP
thioredoxin interacting protein
chr6_+_26264531 1.052 HIST1H1E
histone cluster 1, H1e
chr14_+_38772870 1.048 NM_054024
MIA2
melanoma inhibitory activity 2
chr3_-_42892195 1.029 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr4_+_88076418 1.021


chr6_+_26264537 1.011 NM_005321
HIST1H1E
histone cluster 1, H1e
chrX_-_55037235 0.973 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr6_+_131190237 0.969 NM_001195597
LOC285733
hypothetical LOC285733
chr1_-_181889070 0.928 NM_203454
APOBEC4
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr6_-_138862271 0.899 NM_001144060
NHSL1
NHS-like 1
chr7_+_29486010 0.865 NM_001039936
CHN2
chimerin (chimaerin) 2
chr4_-_88076328 0.857


chr4_-_110942783 0.846 NM_000204
CFI
complement factor I
chr4_+_74500748 0.785 ALB
albumin
chr10_+_114123765 0.785 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_-_177106702 0.781 NM_004673
ANGPTL1
angiopoietin-like 1
chr14_+_22859236 0.777 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr4_-_186970366 0.773 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr10_+_7785347 0.764 ITIH2
inter-alpha (globulin) inhibitor H2
chr9_-_14900992 0.721 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr4_+_140806536 0.709 MGST2
microsomal glutathione S-transferase 2
chr7_+_129057152 0.705 NM_001040110
NRF1
nuclear respiratory factor 1
chr18_+_9092618 0.686 NM_021074
NDUFV2
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr6_+_32515596 0.683 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr2_+_228386800 0.678 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chrX_+_7147471 0.664 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr2_-_74915722 0.657


chr10_+_4995685 0.644 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr7_+_45899621 0.643


chr4_+_187424336 0.641 F11
coagulation factor XI
chr6_+_64344307 0.619 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr6_-_43384507 0.608 NM_206922
CRIP3
cysteine-rich protein 3
chr10_-_69267774 0.603 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr9_-_103185621 0.600 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr2_-_233349469 0.595 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr17_-_76720342 0.590 AATK
apoptosis-associated tyrosine kinase
chr11_+_63829616 0.582 NM_004451
ESRRA
estrogen-related receptor alpha
chr8_-_33490094 0.575 NM_025115
NM_001102401
C8orf41

chromosome 8 open reading frame 41

chr2_-_218865451 0.572 NM_022152
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr10_+_114123828 0.572 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr7_+_1092968 0.571 NM_001039966
NM_001505
GPER

G protein-coupled estrogen receptor 1

chr10_-_11614279 0.568 NM_001080491
USP6NL
USP6 N-terminal like
chr6_+_126282078 0.562 NCOA7
nuclear receptor coactivator 7
chr4_-_159312973 0.559 FAM198B
family with sequence similarity 198, member B
chr4_+_140806371 0.551 NM_002413
MGST2
microsomal glutathione S-transferase 2
chr4_+_187424111 0.547 NM_000128
F11
coagulation factor XI
chr2_+_176842368 0.543 NM_006554
MTX2
metaxin 2
chr5_+_176449156 0.537 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr2_-_152392935 0.526 ARL5A
ADP-ribosylation factor-like 5A
chr1_-_100003936 0.521 NM_001013660
FRRS1
ferric-chelate reductase 1
chr10_+_114033403 0.501 NM_058222
TECTB
tectorin beta
chr14_+_87560646 0.500 LOC283587
hypothetical protein LOC283587
chr3_-_173723754 0.493 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr7_+_45899080 0.479 IGFBP1
insulin-like growth factor binding protein 1
chr12_+_61645361 0.479 RPL14
ribosomal protein L14
chr3_-_156904690 0.476 NM_014996
PLCH1
phospholipase C, eta 1
chr2_+_99163968 0.473 NM_145212
MRPL30
mitochondrial ribosomal protein L30
chr21_+_39117064 0.473 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr7_-_1562272 0.468 NM_001097620
TMEM184A
transmembrane protein 184A
chr4_-_155731288 0.465 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr17_-_25685175 0.463 NM_206832
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr6_+_26153590 0.460 NM_003531
HIST1H3C
histone cluster 1, H3c
chr10_-_5035967 0.460 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr1_-_41398126 0.454 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr10_+_4995597 0.445 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr12_+_102859354 0.434 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr19_-_5790702 0.432 NM_000150
NM_001040701
FUT6

fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

chr2_+_143351695 0.430 KYNU
kynureninase
chr9_-_74757735 0.425 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr11_+_20001130 0.416 NM_001111019
NAV2
neuron navigator 2
chr12_-_121767272 0.415 NM_006018
GPR109B
G protein-coupled receptor 109B
chr13_+_23042722 0.414 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr14_+_38720085 0.413 PNN
pinin, desmosome associated protein
chr9_-_85773899 0.401 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr3_+_173043832 0.399 NM_001164436
TMEM212
transmembrane protein 212
chr12_-_9123126 0.393 A2M
alpha-2-macroglobulin
chr2_+_68445821 0.386 NM_002664
PLEK
pleckstrin
chr1_-_24112345 0.385 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr1_-_149214063 0.384 NM_022075
NM_181746
LASS2

LAG1 homolog, ceramide synthase 2

chr11_+_62813947 0.382 NM_001039752
SLC22A10
solute carrier family 22, member 10
chr6_+_26212082 0.369 NM_003542
HIST1H4C
histone cluster 1, H4c
chr1_+_61315378 0.368


chr2_+_190248955 0.367 NM_144708
ANKAR
ankyrin and armadillo repeat containing
chr1_+_61315516 0.366 NM_001145511
NFIA
nuclear factor I/A
chrX_+_70255128 0.364 NM_005120
MED12
mediator complex subunit 12
chr1_+_153222393 0.361 NM_001184891
NM_001184892
NM_025207
NM_201398
FLAD1



FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)



chr5_-_78317444 0.359 NM_198709
ARSB
arylsulfatase B
chr10_+_4995453 0.356 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr4_+_74520796 0.339 NM_001134
AFP
alpha-fetoprotein
chr9_+_130724382 0.337 NM_001100877
PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chr3_-_180452338 0.336 NM_171830
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr5_+_161210280 0.336 NM_001127648
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr2_-_188086612 0.336 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr20_+_16312 0.335 NM_153325
DEFB125
defensin, beta 125
chr20_-_23534512 0.334 NM_001008693
CST9
cystatin 9 (testatin)
chr22_+_18318459 0.334 NM_001135161
COMT
catechol-O-methyltransferase
chr14_-_106241445 0.333 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr12_+_111829191 0.333 OAS1
2',5'-oligoadenylate synthetase 1, 40/46kDa
chr10_+_101532450 0.333 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr3_-_102878301 0.332 NM_014415
ZBTB11
zinc finger and BTB domain containing 11
chr11_+_8016755 0.331 NM_003320
TUB
tubby homolog (mouse)
chr4_-_39199527 0.331 UGDH
UDP-glucose 6-dehydrogenase
chr6_-_31668476 0.329 NM_001145466
NM_001145467
NM_147130
NCR3


natural cytotoxicity triggering receptor 3


chr1_+_153222464 0.329 FLAD1
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
chr13_+_96592051 0.326 MBNL2
muscleblind-like 2 (Drosophila)
chr14_+_31868229 0.325 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr6_-_108252200 0.324 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr14_-_106330781 0.321 IGHV5-78
immunoglobulin heavy variable 5-78 pseudogene
chr2_-_231697999 0.321 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr18_+_27425727 0.321 NM_000371
TTR
transthyretin
chr1_+_168381811 0.320 NM_001136107
METTL11B
methyltransferase like 11B
chr6_-_116707778 0.314 TSPYL1
TSPY-like 1
chr2_+_68445936 0.313 PLEK
pleckstrin
chr17_-_38385511 0.301 NM_025267
AARSD1
alanyl-tRNA synthetase domain containing 1
chr3_-_9895633 0.300 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr3_+_45902999 0.299 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr10_-_73518772 0.294 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr1_-_180627934 0.294 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr6_+_131936057 0.290 NM_000045
ARG1
arginase, liver
chr7_+_80105907 0.284 CD36
CD36 molecule (thrombospondin receptor)
chr6_+_64414389 0.284 NM_015153
PHF3
PHD finger protein 3
chr1_+_149877955 0.283 SNX27
sorting nexin family member 27
chr11_-_55987452 0.281 NM_001004743
OR5M9
olfactory receptor, family 5, subfamily M, member 9
chr4_-_123761615 0.279 NM_021803
IL21
interleukin 21
chr16_+_82540172 0.279 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr4_-_41445479 0.279 PHOX2B
paired-like homeobox 2b
chr2_-_152393128 0.279 ARL5A
ADP-ribosylation factor-like 5A
chr2_+_132196533 0.278 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr2_-_43919392 0.276 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr12_+_7833261 0.276 NM_024865
NANOG
Nanog homeobox
chr17_-_15463742 0.274 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr3_+_109504021 0.267 NM_007072
HHLA2
HERV-H LTR-associating 2
chr12_+_111829121 0.267 NM_001032409
NM_002534
NM_016816
OAS1


2',5'-oligoadenylate synthetase 1, 40/46kDa


chr2_+_99164064 0.266 MRPL30
mitochondrial ribosomal protein L30
chr16_+_52081836 0.264 RBL2
retinoblastoma-like 2 (p130)
chr2_-_180135559 0.262 NM_001113398
ZNF385B
zinc finger protein 385B
chr9_-_13240313 0.258 NM_003829
MPDZ
multiple PDZ domain protein
chr19_-_45141473 0.257 LOC440525
PRR13
proline rich 13 pseudogene
proline rich 13
chr7_+_80105718 0.254 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chrX_+_128741578 0.253 SASH3
SAM and SH3 domain containing 3
chr9_+_130485926 0.251 SET
SET nuclear oncogene
chr14_-_94053933 0.247 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr5_+_68702617 0.247 NM_133340
NM_133341
RAD17

RAD17 homolog (S. pombe)

chr14_-_34414603 0.245 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr1_-_93172119 0.245


chr10_+_91488704 0.244 KIF20B
kinesin family member 20B
chr9_+_2707525 0.240 NM_133497
KCNV2
potassium channel, subfamily V, member 2
chr16_+_28850760 0.239 NM_001178098
NM_001770
CD19

CD19 molecule

chr10_+_124141808 0.239 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr12_+_25096472 0.239 NM_006152
LRMP
lymphoid-restricted membrane protein
chr15_-_32398220 0.237 NM_005135
SLC12A6
solute carrier family 12 (potassium/chloride transporters), member 6
chr20_-_18425811 0.237 NM_006606
RBBP9
retinoblastoma binding protein 9
chr2_+_143351536 0.237 NM_001032998
NM_003937
KYNU

kynureninase

chr4_+_185063421 0.236 NM_020225
STOX2
storkhead box 2
chr19_+_59820413 0.236 NM_006669
LILRB1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr6_-_27890496 0.235 NM_021066
HIST1H2AJ
histone cluster 1, H2aj
chr12_+_9713472 0.231 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr7_-_122126422 0.230 NM_139175
RNF133
ring finger protein 133
chr11_+_20000938 0.230 NAV2
neuron navigator 2
chr6_+_167445284 0.229 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr2_-_37397669 0.229 NM_005813
PRKD3
protein kinase D3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.27 7.84e-06 GO:0006955 immune response
2.53 8.56e-05 GO:0007606 sensory perception of chemical stimulus
1.87 1.00e-04 GO:0002376 immune system process
2.55 3.14e-04 GO:0007608 sensory perception of smell
1.29 4.08e-04 GO:0050896 response to stimulus
1.92 5.83e-03 GO:0007600 sensory perception
1.93 6.68e-03 GO:0006952 defense response
1.68 8.69e-03 GO:0050877 neurological system process
2.42 9.69e-03 GO:0045087 innate immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.35 3.33e-04 GO:0071944 cell periphery
1.35 4.53e-04 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.99 1.29e-07 GO:0004888 transmembrane receptor activity
1.70 8.61e-07 GO:0004871 signal transducer activity
1.70 8.61e-07 GO:0060089 molecular transducer activity
1.77 2.00e-06 GO:0004872 receptor activity
2.06 3.65e-05 GO:0004930 G-protein coupled receptor activity
2.61 6.68e-05 GO:0004984 olfactory receptor activity
5.40 3.72e-02 GO:0003823 antigen binding